Super Anti-oxidants capsules
- Curcuma longa (turmeric)
- Curcuma aromatica (wild turmeric)
- Curcuma Zedoaria (white turmeric)
- Black pepper
Powerful Anti-ageing, antioxidant and anti-cancer properties with a wide spectrum of biological functions.
Curcumin is the main active ingredient in Curcuma herbs in Zingiberaceae Family
The Curcumins are found to be Powerful Anti-ageing, Powerful antioxidant and Anti cancer.
Curcumins increases the Antioxidant Capacity greatly.
Free Radicals are the main cause for rapid ageing, body decay and breakdown, cancerd, amaging the body in a serious way.
Studies have shown that curcuminoids are very effective in scavenging free radicals and neutralize them. Thus if our body mechanism is not able to fight with these free radicals, turmeric can assist our body to do so very effectively.
It is also believed to have capability of preventing development of free radicals itself. Thus it reduces the risk of damage by free radicals drastically. The mechanism through which turmeric does this is by blocking oxidizing capabilities of metals in body
(reduce iron complex and inhibit peroxidation). Regular intake of turmeric can help body fight back free radicals and save it from diseases and cell damage.
Curcumin not only fights and reduces free radicals it also helps free radical fighting or anti-oxidant enzymes (superoxide dismutase, catalase, etc.) present in our body to do so. Turmeric increases the number and enhances the activity of these anti-oxidant enzymes.
Curcumin is a potent antioxidant that can neutralize free radicals according to its chemical structure of phenolic nature. (1, 2).
Curcumin also boosts the activity of the body’s own antioxidant enzymes (3, 4, 5).
In that way, curcumin delivers a one-two punch against free radicals. It blocks them directly, then stimulates the body’s own antioxidant mechanisms.
Curcumin also helps create the master anti-oxidant glutathione.
How Effective of Turmeric as Anti-oxidant
Comparisons between common anti-oxidants and turmeric (curcuminoids):
- Vitamin E is well known for its anti-oxidant properties. Turmeric is 5 to 8 times stronger anti-oxidant that vitamin E
- Vitamin C. the anti-oxidant property of turmeric is even stronger than that of Vitamin C. Song et al 2001, pointed out that it is as much as 10 times more effective than Vitamin C.Turmeric is more powerful anti-oxidant as compared to grape seed, eugenol (from cloves), capsaicin (from cayenne).
- Turmeric is found to be very effective against one of the most reactive free radical – hydroxyl radical.
- Turmeric helps in preventing protein glycosylation and lipid peroxidation. (Jain et al 2006)
Other benefits of Turmerics:
Treating gastric ulcers effectivelyAnti-Inflammatory which in some trials, the curcumins was even more effective than some anti-inflammatory drugs
Anti-cancer, protection against tumors, cell mutation, cancer
Lower Risk of Heart Diseases, keep heart healthy by removing oxidized cholesterol from body. Also it helps in reducing oxidative stress, known to the cause of heart problems.Anti-cancer activities
Preventing and Treating Alzheimer’s
Relieve and Treat rheumatoid, joints problems, Curcumin has proven even better for relieving arthritis pains and stiffness than expensive pharmaceuticals, without side effects.
It has also been proven to protect the liver and gallbladder.
and much more benefits ....
Optimize Turmeric Absorption For Super-Boosted Benefits
Turmeric is fat-soluble, that means it dissolves in fat. In order to make the most of turmeric, you must take it with a bit of fat, oils such as virgin coconut oil.
Consume turmeric with black pepper. “Adding black pepper to turmeric or turmeric-spiced food enhances curcumin’s bioavailability , due to black pepper’s hot property called piperine.
To benefit from its anti-oxidant properties, it is recommended to take on daily basis. Studies have shown that pausing turmeric
dosage again increases the activity of free radicals.
Turmeric has become one of active ingredients in many anti-aging supplements.
Source: authoritynutrition.com, turmericforhealth.com
------------------------------------------------------------------------------------------------
References:
1. Adv Exp Med Biol. 2007;595:105-25.
Antioxidant and anti-inflammatory properties of curcumin.
Menon VP1, Sudheer AR.
Abstract
Curcumin, a yellow pigment from Curcuma longa, is a major component of turmeric and is commonly used as a spice and food-coloring
agent. It is also used as a cosmetic and in some medical preparations. The desirable preventive or putative therapeutic
properties of curcumin have also been considered to be associated with its antioxidant and anti-inflammatory properties. Because
free-radical-mediated peroxidation of membrane lipids and oxidative damage of DNA and proteins are believed to be associated with
a variety of chronic pathological complications such as cancer, atherosclerosis, and neurodegenerative diseases, curcumin is
thought to play a vital role against these pathological conditions. The anti-inflammatory effect of curcumin is most likely
mediated through its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS).
COX-2, LOX, and iNOS are important enzymes that mediate inflammatory processes. Improper upregulation of COX-2 and/or iNOS has
been associated with the pathophysiology of certain types of human cancer as well as inflammatory disorders. Because inflammation
is closely linked to tumor promotion, curcumin with its potent anti-inflammatory property is anticipated to exert chemopreventive
effects on carcinogenesis. Hence, the past few decades have witnessed intense research devoted to the antioxidant and anti-
inflammatory properties of curcumin. In this review, we describe both antioxidant and anti-inflammatory properties of curcumin,
the mode of action of curcumin, and its therapeutic usage against different pathological conditions.
PMID: 17569207 [PubMed - indexed for MEDLINE]
2. On the Antioxidant Mechanism of Curcumin: Classical Methods Are Needed To Determine Antioxidant Mechanism and Activity
L. Ross C. Barclay * and Melinda R. Vinqvist
Department of Chemistry, Mount Allison University, Sackville, New Brunswick, Canada E4L 1G8
Kazuo Mukai ,† Hideo Goto ,† Yoshimi Hashimoto ,† Aiko Tokunaga ,† and Hidemitsu Uno ‡
Department of Chemistry and Advanced Instrumentation Center for Chemical Analysis, Ehime University, Matsuyama, 790-8577 Japan
Org. Lett., 2000, 2 (18), pp 2841–2843
DOI: 10.1021/ol000173t
Publication Date (Web): August 18, 2000
Copyright © 2000 American Chemical Society
Abstract
The antioxidant activity of curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) was determined by inhibition
of controlled initiation of styrene oxidation. Synthetic nonphenolic curcuminoids exhibited no antioxidant activity; therefore,
curcumin is a classical phenolic chain-breaking antioxidant, donating H atoms from the phenolic groups not the CH2 group as has
been suggested (Jovanovic et al. J. Am. Chem. Soc. 1999, 121, 9677). The antioxidant activities of o-methoxyphenols are decreased
in hydrogen bond accepting media.
3. Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury
Rakhi Agarwal1,†, Sudhir K. Goel2,* andJai Raj Behari1
Article first published online: 12 MAR 2010
DOI: 10.1002/jat.1517
Keywords:
mercury;curcumin;oxidative stress;antioxidant defense system;histopathology;MT expression
Abstract
Curcumin, a safe nutritional component and a highly promising natural antioxidant with a wide spectrum of biological functions,
has been examined in several metal toxicity studies, but its role in protection against mercury toxicity has not been
investigated. Therefore, the detoxification and antioxidant effects of curcumin were examined to determine its
prophylactic/therapeutic role in rats experimentally exposed to mercury (in the from of mercuric chloride-HgCl2, 12 µmol kg−1
b.w. single intraperitoneal injection). Curcumin treatment (80 mg kg−1 b.w. daily for 3 days, orally) was found to have a
protective effect on mercury-induced oxidative stress parameters, namely, lipid peroxidation and glutathione levels and
superoxide dismutase, glutathione peroxidase and catalase activities in the liver, kidney and brain. Curcumin treatment was also
effective for reversing mercury-induced serum biochemical changes, which are the markers of liver and kidney injury. Mercury
concentration in the tissues was also decreased by the pre/post-treatment with curcumin. However, histopathological alterations
in the liver and kidney were not reversed by curcumin treatment. Mercury exposure resulted in the induction of metallothionein
(MT) mRNA expressions in the liver and kidney. Metallothionein mRNA expression levels were found to decrease after the pre-
treatment with curcumin, whereas post-treatment with curcumin further increased MT mRNA expression levels. Our findings suggest
that curcumin pretreatment has a protective effect and that curcumin can be used as a therapeutic agent in mercury intoxication.
The study indicates that curcumin, an effective antioxidant, may have a protective effect through its routine dietary intake
against mercury exposure.
4. Toxicological & Environmental Chemistry Volume 95, Issue 6, 2013
Protective effects of curcumin on antioxidant status, body weight gain, and reproductive parameters in male rats exposed to subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin
DOI:10.1080/02772248.2013.829061
Funda Gülcü Bulmuşa*, Fatih Sakinb, Gaffari Türkc, Mustafa Sönmezc & Kadir Servid
pages 1019-1029
Publishing models and article dates explained
Received: 24 May 2013
Accepted: 18 Jul 2013
Published online: 25 Aug 2013
Abstract
The aim of this study was to investigate the effects of curcumin (CUR) on antioxidant status, body weight (BW) gains, and some
reproductive parameters in male rats exposed to subchronic doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Thirty-two rats
were divided into four groups. The first group was kept as control. The second group (TCDD group) was given TCDD at a dose of 50
ng·kg−1 BW per day; the third group (CUR group) was treated with CUR at a dose of 80 mg·kg−1 BW per day. The fourth group (TCDD +
CUR group) was given TCDD and CUR at the same doses simultaneously. Malondialdehyde (MDA) levels were significantly increased in
the TCDD group. In addition, TCDD exposure decreased liver superoxide dismutase (SOD) activity, catalase (CAT) activities of
kidney and brain, glutathione peroxidase (GSH-Px) activities of liver, kidney, and brain, and glutathione levels of liver,
kidney, and heart. However, CUR treatment with TCDD exposure decreased MDA levels in all tissues and increased SOD activities of
liver, kidney, and brain, CAT activity of heart, and GSH-Px activities of heart and brain. TCDD caused a decrease in BW gain, and
CUR partially eliminated this effect of TCDD. In addition, while reproductive organ weights, sperm concentration, and sperm
motility tended to decrease with TCDD exposure, these effects tended to be close to normal levels by CUR treatment. In
conclusion, CUR was seen to be effective in the treatment and prevention of toxicity induced by subchronic TCDD exposure.
5. Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):32-41.
Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial
cells: mechanism of free radical scavenging activity.
Biswas SK1, McClure D, Jimenez LA, Megson IL, Rahman I.
Abstract
Oxidants and tumor necrosis factor-alpha (TNF-alpha) activate transcription factors such as nuclear factor-kappaB (NF-kappaB),
which is involved in the transcription of proinflammatory mediators, including interleukin-8 (IL-8). Curcumin (diferuloylmethane)
is a naturally occurring flavonoid present in the spice turmeric, which has a long traditional use as a chemotherapeutic agent
for many diseases. We hypothesize that curcumin may possess both antioxidant and antiinflammatory properties by increasing the
glutathione levels and inhibiting oxidant- and cytokine-induced NF-kappaB activation and IL-8 release from cultured alveolar
epithelial cells (A549). Treatment of A549 cells with hydrogen peroxide (H2O2; 100 microM) and TNF-alpha (10 ng/ml) significantly
increased NF-kappaB and activator protein-1 (AP-1) activation, as well as IL-8 release. Curcumin inhibited both H2O2- and TNF-
alpha-mediated activation of NF-kappaB and AP-1, and IL-8 release. Furthermore, an increased level of GSH and glutamylcysteine
ligase catalytic subunit mRNA expression was observed in curcumin-treated cells as compared with untreated cells. Curcumin
interacted directly with superoxide anion (O2*-) and hydroxyl radical (*OH) as shown by electron paramagnetic resonance,
quenching the interaction of the radicals with the spin trap, Tempone-H. This suggests that curcumin has multiple properties: as
an oxygen radical scavenger, antioxidant through modulation of glutathione levels, and antiinflammatory agent through inhibition
of IL-8 release in lung cells.
PMID: 15650394 [PubMed - indexed for MEDLINE]
No comments:
Post a Comment